Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Lhx6  LIM homeobox protein 6
Results	Reference
1	J:328140 Asgarian Z, Oliveira MG, Stryjewska A, Maragkos I, Rubin AN, Magno L, Pachnis V, Ghorbani M, Hiebert SW, Denaxa M, Kessaris N, MTG8 interacts with LHX6 to specify cortical interneuron subtype identity. Nat Commun. 2022 Sep 5;13(1):5217
1	J:154509 Azim E, Jabaudon D, Fame RM, Macklis JD, SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development. Nat Neurosci. 2009 Oct;12(10):1238-47
1*	J:207154 Balasubramanian R, Bui A, Ding Q, Gan L, Expression of LIM-homeodomain transcription factors in the developing and mature mouse retina. Gene Expr Patterns. 2014 Jan;14(1):1-8
1	J:154935 Batista-Brito R, Rossignol E, Hjerling-Leffler J, Denaxa M, Wegner M, Lefebvre V, Pachnis V, Fishell G, The cell-intrinsic requirement of Sox6 for cortical interneuron development. Neuron. 2009 Aug 27;63(4):466-81
1*	J:168654 Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL, Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):84-92
1	J:126582 Cobos I, Borello U, Rubenstein JL, Dlx transcription factors promote migration through repression of axon and dendrite growth. Neuron. 2007 Jun 21;54(6):873-88
1	J:101437 Cobos I, Calcagnotto ME, Vilaythong AJ, Thwin MT, Noebels JL, Baraban SC, Rubenstein JL, Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy. Nat Neurosci. 2005 Aug;8(8):1059-68
1	J:154438 Cobos I, Long JE, Thwin MT, Rubenstein JL, Cellular patterns of transcription factor expression in developing cortical interneurons. Cereb Cortex. 2006 Jul;16 Suppl 1:i82-8
1	J:121077 Colombo E, Collombat P, Colasante G, Bianchi M, Long J, Mansouri A, Rubenstein JL, Broccoli V, Inactivation of Arx, the murine ortholog of the X-linked lissencephaly with ambiguous genitalia gene, leads to severe disorganization of the ventral telencephalon with impaired neuronal migration and differentiation. J Neurosci. 2007 Apr 25;27(17):4786-98
1	J:196342 Denaxa M, Kalaitzidou M, Garefalaki A, Achimastou A, Lasrado R, Maes T, Pachnis V, Maturation-promoting activity of SATB1 in MGE-derived cortical interneurons. Cell Rep. 2012 Nov 29;2(5):1351-62
1	J:133494 Elshatory Y, Gan L, The LIM-homeobox gene Islet-1 is required for the development of restricted forebrain cholinergic neurons. J Neurosci. 2008 Mar 26;28(13):3291-7
1	J:336861 Folorunso OO, Brown SE, Baruah J, Harvey TL, Jami SA, Radzishevsky I, Wolosker H, McNally JM, Gray JA, Vasudevan A, Balu DT, D-serine availability modulates prefrontal cortex inhibitory interneuron development and circuit maturation. Sci Rep. 2023 Jun 13;13(1):9595
1	J:163224 Garcia-Lopez M, Abellan A, Legaz I, Rubenstein JL, Puelles L, Medina L, Histogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during development. J Comp Neurol. 2008 Jan 1;506(1):46-74
1*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1*	J:48134 Grigoriou M, Tucker AS, Sharpe PT, Pachnis V, Expression and regulation of Lhx6 and Lhx7, a novel subfamily of LIM homeodomain encoding genes, suggests a role in mammalian head development. Development. 1998 Jun;125(11):2063-74
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:191332 Henry AM, Hohmann JG, High-resolution gene expression atlases for adult and developing mouse brain and spinal cord. Mamm Genome. 2012 Oct;23(9-10):539-49
1	J:224836 Hoch RV, Lindtner S, Price JD, Rubenstein JL, OTX2 Transcription Factor Controls Regional Patterning within the Medial Ganglionic Eminence and Regional Identity of the Septum. Cell Rep. 2015 Jul 21;12(3):482-94
1	J:150700 Kimura N, Ueno M, Nakashima K, Taga T, A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains. J Biochem. 1999 Jul;126(1):180-7
1	J:334504 Kounoupa Z, Tivodar S, Theodorakis K, Kyriakis D, Denaxa M, Karagogeos D, Rac1 and Rac3 GTPases and TPC2 are required for axonal outgrowth and migration of cortical interneurons. J Cell Sci. 2023 Mar 15;136(6):jcs260373
1	J:284900 Larsen R, Proue A, Scott EP, Christiansen M, Nakagawa Y, The Thalamus Regulates Retinoic Acid Signaling and Development of Parvalbumin Interneurons in Postnatal Mouse Prefrontal Cortex. eNeuro. 2019 Jan-Feb;6(1):ENEURO.0018-19.2019
1	J:306387 Limoni G, Murthy S, Jabaudon D, Dayer A, Niquille M, PlexinA4-Semaphorin3A-mediated crosstalk between main cortical interneuron classes is required for superficial interneuron lamination. Cell Rep. 2021 Jan 26;34(4):108644
1	J:119476 Liodis P, Denaxa M, Grigoriou M, Akufo-Addo C, Yanagawa Y, Pachnis V, Lhx6 activity is required for the normal migration and specification of cortical interneuron subtypes. J Neurosci. 2007 Mar 21;27(12):3078-89
1*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1	J:184343 Magno L, Kretz O, Bert B, Ersozlu S, Vogt J, Fink H, Kimura S, Vogt A, Monyer H, Nitsch R, Naumann T, The integrity of cholinergic basal forebrain neurons depends on expression of Nkx2-1. Eur J Neurosci. 2011 Dec;34(11):1767-82
1	J:227683 Marin O, Anderson SA, Rubenstein JL, Origin and molecular specification of striatal interneurons. J Neurosci. 2000 Aug 15;20(16):6063-76
1	J:74989 McEvilly RJ, de Diaz MO, Schonemann MD, Hooshmand F, Rosenfeld MG, Transcriptional regulation of cortical neuron migration by POU domain factors. Science. 2002 Feb 22;295(5559):1528-32
1	J:197761 McKinsey GL, Lindtner S, Trzcinski B, Visel A, Pennacchio LA, Huylebroeck D, Higashi Y, Rubenstein JL, Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons. Neuron. 2013 Jan 9;77(1):83-98
1*	J:205051 Miller JA, Nathanson J, Franjic D, Shim S, Dalley RA, Shapouri S, Smith KA, Sunkin SM, Bernard A, Bennett JL, Lee CK, Hawrylycz MJ, Jones AR, Amaral DG, Sestan N, Gage FH, Lein ES, Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
1	J:100340 Mori T, Yuxing Z, Takaki H, Takeuchi M, Iseki K, Hagino S, Kitanaka J, Takemura M, Misawa H, Ikawa M, Okabe M, Wanaka A, The LIM homeobox gene, L3/Lhx8, is necessary for proper development of basal forebrain cholinergic neurons. Eur J Neurosci. 2004 Jun;19(12):3129-41
1	J:233500 Nishimura S, Bilguvar K, Ishigame K, Sestan N, Gunel M, Louvi A, Functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development. PLoS One. 2015;10(4):e0124295
1	J:198037 Paschou P, Stylianopoulou E, Karagiannidis I, Rizzo R, Tarnok Z, Wolanczyk T, Hebebrand J, Nothen MM, Lehmkuhl G, Farkas L, Nagy P, Szymanska U, Lykidis D, Androutsos C, Tsironi V, Koumoula A, Barta C, Klidonas S, Ypsilantis P, Simopoulos C, Skavdis G, Grigoriou M, Evaluation of the LIM homeobox genes LHX6 and LHX8 as candidates for Tourette syndrome. Genes Brain Behav. 2012 Jun;11(4):444-51
1	J:99763 Pozas E, Ibanez CF, GDNF and GFRalpha1 promote differentiation and tangential migration of cortical GABAergic neurons. Neuron. 2005 Mar 3;45(5):701-13
1	J:91847 Remedios R, Subramanian L, Tole S, LIM genes parcellate the embryonic amygdala and regulate its development. J Neurosci. 2004 Aug 4;24(31):6986-90
1*	J:157819 Shimogori T, Lee DA, Miranda-Angulo A, Yang Y, Wang H, Jiang L, Yoshida AC, Kataoka A, Mashiko H, Avetisyan M, Qi L, Qian J, Blackshaw S, A genomic atlas of mouse hypothalamic development. Nat Neurosci. 2010;13(6):767-75
1*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1	J:232769 Tuncdemir SN, Fishell G, Batista-Brito R, miRNAs are Essential for the Survival and Maturation of Cortical Interneurons. Cereb Cortex. 2015 Jul;25(7):1842-57
1	J:327277 Venkataramanappa S, Saaber F, Abe P, Schutz D, Kumar PA, Stumm R, Cxcr4 and Ackr3 regulate allocation of caudal ganglionic eminence-derived interneurons to superficial cortical layers. Cell Rep. 2022 Aug 2;40(5):111157
1	J:193303 Vidaki M, Tivodar S, Doulgeraki K, Tybulewicz V, Kessaris N, Pachnis V, Karagogeos D, Rac1-dependent cell cycle exit of MGE precursors and GABAergic interneuron migration to the cortex. Cereb Cortex. 2012 Mar;22(3):680-92